The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 16, 2024
Filed:
Jul. 07, 2022
Applicant:
Dicerna Pharmaceuticals, Inc., Lexington, MA (US);
Inventors:
Assignee:
DICERNA PHARMACEUTICALS, INC., Lexington, MA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/113 (2010.01); A61K 31/7115 (2006.01); A61K 31/712 (2006.01); A61K 31/7125 (2006.01); A61K 45/06 (2006.01); A61K 47/54 (2017.01); A61K 47/60 (2017.01); C07H 19/10 (2006.01); C07H 21/02 (2006.01); C07H 21/04 (2006.01);
U.S. Cl.
CPC ...
C12N 15/113 (2013.01); A61K 31/7115 (2013.01); A61K 31/712 (2013.01); A61K 31/7125 (2013.01); A61K 45/06 (2013.01); A61K 47/549 (2017.08); A61K 47/60 (2017.08); C07H 19/10 (2013.01); C07H 21/02 (2013.01); C07H 21/04 (2013.01); C12N 2310/14 (2013.01); C12N 2310/31 (2013.01); C12N 2310/322 (2013.01); C12N 2310/344 (2013.01); C12N 2310/3515 (2013.01);
Abstract
Disclosed herein are oligonucleotides, such as nucleic acid inhibitor molecules, having a 4'-phosphate analog and methods of using the same, for example, to modulate the expression of a target gene in a cell. The phosphate analogs are bound to the 4′-carbon of the sugar moiety (e.g., a ribose or deoxyribose or analog thereof) of the 5′-terminal nucleotide of an oligonucleotide. Typically, the phosphate analog is an oxymethylphosphonate, where the oxygen atom of the oxymethyl group is bound to the 4′-carbon of the sugar moiety or analog thereof.