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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12037369 B1

PDFFull Text
Date of Patent:
Jul. 16, 2024

Filed:

Apr. 19, 2021

Cationic neurotoxins

Applicant:

Ipsen Bioinnovation Limited, Abingdon, GB;

Inventors:

Dina Brady Anderson, Abingdon, GB;

Gavin Stephen Hackett, Abingdon, GB;

Sai Man Liu, Abingdon, GB;

Assignee:

IPSEN BIOINNOVATION LIMITED, Abingdon, GB;

Attorneys:

Barnes & Thornburg LLP

Gene J. Yao

Primary Examiner:

Brian Gangle

Int. Cl.
CPC ...
C07K 14/33 (2006.01); A61K 8/64 (2006.01); A61K 8/99 (2017.01); A61K 38/00 (2006.01); A61K 38/48 (2006.01); A61P 17/00 (2006.01); A61P 25/06 (2006.01); A61P 25/08 (2006.01); A61P 25/16 (2006.01); A61Q 19/08 (2006.01);
U.S. Cl.
CPC ...
C07K 14/33 (2013.01); A61K 8/64 (2013.01); A61K 8/99 (2013.01); A61K 38/4893 (2013.01); A61P 17/00 (2018.01); A61P 25/06 (2018.01); A61P 25/08 (2018.01); A61P 25/16 (2018.01); A61Q 19/08 (2013.01); C12Y 304/24069 (2013.01); A61K 38/00 (2013.01);
Abstract

The present invention provides engineered clostridial toxins comprising at least one amino acid modification, wherein said at least one amino acid modification increases the isoelectric point (pi) of the engineered clostridial toxin to a value that is at least 0.2 pi units higher than the pi of an otherwise identical clostridial toxin lacking said at least one amino acid modification, and wherein said at least one amino acid modification is not located in the clostridial toxin binding domain (Hdomain). Also provided are medical uses of the engineered clostridial toxins.

Find Patent Forward Citations

Anderson, Dina. (2024). Cationic neurotoxins (U.S. Patent No. 12037369). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/12037369

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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