The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 16, 2024
Filed:
Apr. 04, 2019
Genethon, Evry, FR;
Institut National DE LA Sante ET DE LA Recherche Medicale, Paris, FR;
Universite D'evry Val D'essonne, Evry, FR;
Sorbonne Universite, Paris, FR;
Association Institut DE Myologie, Paris, FR;
Genethon, Evry, FR;
Institut National de la Sante et de la Recherche Medicale, Paris, FR;
Universite d'Evry val d'Essonne, Evry, FR;
Sorbonne Universite, Paris, FR;
Association Institut de Myologie, Paris, FR;
Abstract
The invention relates to a recombinant adeno-associated virus (AAV) capsid protein, which is a hybrid between AAV serotype 9 (AAV9) and AAV serotype 74 (AAVrh74) capsid proteins, wherein said recombinant hybrid AAV capsid protein has a reduced liver tropism compared to the parent AAV9 and AAVrh74 capsid proteins. The invention relates also to the derived hybrid AAV serotype vector particles packaging a gene of interest and their use in gene therapy, in particular for treating neuromuscular genetic diseases.