IDiyas

For the Inventor, By the Inventor

The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12037324 B1

PDFFull Text
Date of Patent:
Jul. 16, 2024

Filed:

Jul. 11, 2022

Biarylmethyl heterocycles

Applicants:

Université DE Montréal, Montréal, CA;

Bristol-myers Squibb Company, Princeton, NJ (US);

Inventors:

Eldon Scott Priestley, Hopewell, NJ (US);

Samuel Kaye Reznik, Brookline, MA (US);

Edward H. Ruediger, Montreal, CA;

James R. Gillard, Montreal, CA;

Oz Scott Halpern, Hopewell, NJ (US);

Wen Jiang, Hopewell, NJ (US);

Jeremy Richter, Hopewell, NJ (US);

Rejean Ruel, Montreal, CA;

Sasmita Tripathy, Montreal, CA;

Wu Yang, Hopewell, NJ (US);

Xiaojun Zhang, Hopewell, NJ (US);

Assignees:

Bristol-Myers Squibb Company, Princeton, NJ (US);

Université de Montréal, , CA;

Attorney:

Hoffmann & Baron, LLP

Primary Examiner:

Paul V Ward

Int. Cl.
CPC ...
C07D 401/14 (2006.01); A61K 31/41 (2006.01); A61K 31/4245 (2006.01); A61K 31/427 (2006.01); A61K 31/437 (2006.01); A61K 31/4439 (2006.01); A61K 31/4709 (2006.01); A61K 31/497 (2006.01); A61K 31/501 (2006.01); A61P 9/04 (2006.01); C07D 233/90 (2006.01); C07D 235/26 (2006.01); C07D 239/20 (2006.01); C07D 257/04 (2006.01); C07D 271/07 (2006.01); C07D 401/10 (2006.01); C07D 403/10 (2006.01); C07D 403/14 (2006.01); C07D 405/14 (2006.01); C07D 413/10 (2006.01); C07D 413/14 (2006.01); C07D 417/14 (2006.01); C07D 471/04 (2006.01); C07D 498/10 (2006.01);
U.S. Cl.
CPC ...
C07D 401/14 (2013.01); A61K 31/41 (2013.01); A61K 31/4245 (2013.01); A61K 31/427 (2013.01); A61K 31/437 (2013.01); A61K 31/4439 (2013.01); A61K 31/4709 (2013.01); A61K 31/497 (2013.01); A61K 31/501 (2013.01); A61P 9/04 (2018.01); C07D 233/90 (2013.01); C07D 235/26 (2013.01); C07D 239/20 (2013.01); C07D 257/04 (2013.01); C07D 271/07 (2013.01); C07D 401/10 (2013.01); C07D 403/10 (2013.01); C07D 403/14 (2013.01); C07D 405/14 (2013.01); C07D 413/10 (2013.01); C07D 413/14 (2013.01); C07D 417/14 (2013.01); C07D 471/04 (2013.01); C07D 498/10 (2013.01);
Abstract

The present invention provides compounds of Formula (I): wherein all variables are as defined in the specification, and compositions comprising any of such novel compounds. These compounds are biased agonists, or β-Arrestin agonists of the angiotensin II receptor, which may be used as medicaments.

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