logo

For the Inventor, By the Inventor

The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12036384 B1

PDFFull Text
Date of Patent:
Jul. 16, 2024

Filed:

Feb. 05, 2020

Replication or mitigation of low frequency vibration and other physical factors to enhance the effect of thrombolysis on patients with ischemic stroke

Applicant:

University of Iowa Research Foundation, Iowa City, IA (US);

Inventors:

Enrique C. Leira, Iowa City, IA (US);

Thomas Schnell, Iowa City, IA (US);

Salam F. Rahmatalla, Iowa City, IA (US);

Andrew A. Pieper, Iowa City, IA (US);

Anil Chauhan, Iowa City, IA (US);

Assignee:

University of lowa Research Foundation, lowa City, IA (US);

Attorneys:

Dentons Davis Brown

Matthew Warner-Blankenship

Primary Examiner:

Jason E Flick

Int. Cl.
CPC ...
A61M 5/142 (2006.01); A61H 1/00 (2006.01);
U.S. Cl.
CPC ...
A61M 5/142 (2013.01); A61H 1/001 (2013.01); A61H 2201/5048 (2013.01); A61H 2209/00 (2013.01); A61M 2005/14208 (2013.01); A61M 2202/07 (2013.01);
Abstract

The disclosed apparatus, systems and methods relate to devices, systems and methods for improving thrombolysis via synergetic application of thrombolytics with physical factors, such as in acute ischemic stroke patients. Vibration in the low (0.5-120 Hz) frequency range is synergistic with tissue plasminogen activators (rtPA), significantly improving the effectiveness of thrombolysis without impairing blood brain barrier permeability. Administration of low frequency vibration combined with rtPA improve acute ischemic stroke outcomes.

Find Patent Forward Citations

Leira, Enrique. (2024). Replication or mitigation of low frequency vibration and other physical factors to enhance the effect of thrombolysis on patients with ischemic stroke (U.S. Patent No. 12036384). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/12036384

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

Loading…