The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 16, 2024
Filed:
Sep. 08, 2021
Applicant:
The Board of Regents of the University of Texas System, Austin, TX (US);
Inventors:
Jinming Gao, Dallas, TX (US);
Suxin Li, Dallas, TX (US);
Assignee:
The Board of Regents of The University of Texas System, Austin, TX (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 9/107 (2006.01); A61K 31/4184 (2006.01); A61K 31/5377 (2006.01); A61K 31/7076 (2006.01); A61K 47/32 (2006.01); A61P 35/00 (2006.01);
U.S. Cl.
CPC ...
A61K 9/1075 (2013.01); A61K 31/4184 (2013.01); A61K 31/5377 (2013.01); A61K 31/7076 (2013.01); A61K 47/32 (2013.01); A61P 35/00 (2018.01);
Abstract
Described herein are therapeutic pH responsive compositions useful for the treatment of cancer. The compositions involve combining a STING activating polymer micelle, such as PC7A, with a non-peptide STING agonist, such as cGAMP. Methods of administering these compositions in the treatment of cancer are also disclosed. These methods include administration of the pharmaceutical compositions by intratumoral injection in the treatment of solid tumors.