The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 16, 2024
Filed:
May. 04, 2022
Industry-university Cooperation Foundation Hanyang University Erica Campus, Gyeonggi-do, KR;
Chul-Su Yang, Gyeonggi-do, KR;
Jae-Sung Kim, Gyeonggi-do, KR;
Abstract
The present disclosure is the first to identify a host cell protein and its function with which MPT63 and MPT64, secreted antigens of, interact, and to construct a recombinant MPT protein including each domain of MPT63 and MPT64 interacting with the host cell protein, and the recombinant MPT protein may be applied to a use for the prevention and treatment of tuberculosis by confirming that the recombinant MPT protein targets the-infected macrophages and increases the ROS level and inflammatory cytokine expression in macrophages, thereby inducing the death of. And MPT protein of the present disclosure can improve the vaccine effect by the BCG vaccine so that it can be used as a tuberculosis vaccine and/or vaccine adjuvant either alone or together with known tuberculosis vaccines.