The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 09, 2024
Filed:
Dec. 27, 2018
Takeda Pharmaceutical Company Limited, Osaka, JP;
Akitsu Hotta, Kyoto, JP;
Masataka Ifuku, Kyoto, JP;
Naoko Fujimoto, Kyoto, JP;
Kumiko Iwabuchi, Kyoto, JP;
Eriya Kenjo, Kanagawa, JP;
Yukimasa Makita, Kanagawa, JP;
Rumiko Ochiai, Kanagawa, JP;
TAKEDA PHARMACEUTICAL COMPANY LIMITED, Osaka, JP;
Abstract
The present invention provides a delivery technique for delivering a gene modification tool capable of providing a high gene modification efficiency in cells. The composition according to the present invention is a composition for inducing gene modification at a target gene locus in a cell, the composition containing 1) a compound represented by formula (I) or a salt thereof; 2) a structural lipid; and 3) a guide RNA or a DNA including a sequence encoding the guide RNA, and/or an RNA-guided nuclease or a nucleic acid including a sequence encoding the RNA-guided nuclease. In formula (I), n represents an integer of 2 to 5, R represents a linear Calkyl group, a linear Calkenyl group, or a linear Calkadienyl group, and wavy lines each independently represent a cis-type bond or a trans-type bond.