The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 09, 2024
Filed:
May. 28, 2019
Hangzhou Sumgen Biotech Co., Ltd., Zhejiang, CN;
Sumgen Mab (Beijing) Biotech Co., Ltd., Beijing, CN;
Ming Lv, Zhejiang, CN;
Xiaoran Ding, Zhejiang, CN;
Shiwei Miao, Zhejiang, CN;
Bin Tan, Zhejiang, CN;
Xuegong Wang, Zhejiang, CN;
HANGZHOU SUMGEN BIOTECH CO., LTD., Zhejiang, CN;
SUMGEN MAB (BEIJING) BIOTECH CO., LTD., Beijing, CN;
Abstract
Provided is an antibody or an antigen-binding fragment thereof, having one or more properties selected from the group consisting of: 1) being capable of binding to an AXL protein by a Kvalue of 1×10M or lower; 2) being capable of specifically recognizing an AXL protein expressed on a cell surface; and 3) being capable of mediating internalization after binding to the AXL protein expressed on the cell surface. The antibody may further used for constructing an immunoconjugate. The antibody and the immunoconjugate may inhibit the proliferation of tumor cells.