The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 09, 2024
Filed:
Oct. 29, 2021
Applicant:
Adverum Biotechnologies, Inc., Redwood City, CA (US);
Inventor:
Annahita Keravala, Palo Alto, CA (US);
Assignee:
Adverum Biotechnologies, Inc., Redwood City, CA (US);
Primary Examiner:
Int. Cl.
CPC ...
C07K 14/005 (2006.01); A61K 9/00 (2006.01); A61K 48/00 (2006.01); C12N 7/00 (2006.01); C12N 15/86 (2006.01);
U.S. Cl.
CPC ...
C07K 14/005 (2013.01); A61K 9/0048 (2013.01); A61K 48/0008 (2013.01); A61K 48/0075 (2013.01); C12N 7/00 (2013.01); C12N 15/86 (2013.01); C12N 2750/14121 (2013.01); C12N 2750/14122 (2013.01); C12N 2750/14133 (2013.01); C12N 2750/14143 (2013.01); C12N 2750/14171 (2013.01);
Abstract
The present disclosure provides adeno-associated virus (AAV) virions with altered capsid protein that binds heparan sulfate proteoglycans, where the AAV virions exhibit greater infectivity of retinal cells, altered tropism and/or the ability to bind and cross the inner limiting membrane following intravitreal injection. The present disclosure further provides methods of delivering a gene product to a retinal cell in an individual, and methods of treating ocular disease.