The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jul. 09, 2024

Filed:

Nov. 16, 2022
Applicants:

The Trustees of Indiana University, Indianapolis, IN (US);

The Board of Trustees of the University of Illinois, Urbana, IL (US);

Inventors:

Tom G. Driver, Chicago, IL (US);

Roberto F. Machado, Carmel, IN (US);

Naijing Su, Newark, DE (US);

Xinyu Guan, Chicago, IL (US);

Wrickban Mazumdar, Chicago, IL (US);

Kira Ratia, Chicago, IL (US);

Jason Ralph Hickok, Chicago, IL (US);

Angelia Denise Lockett, Indianapolis, IN (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07F 7/08 (2006.01); C07D 401/12 (2006.01); C07D 491/056 (2006.01);
U.S. Cl.
CPC ...
C07F 7/0816 (2013.01); C07D 401/12 (2013.01); C07D 491/056 (2013.01);
Abstract

Disclosed herein are compounds that can act as inhibitors of nicotinamide phosphoribosyltransferase ('NAMPT'), and methods for their use in treating or preventing diseases, such as pulmonary arterial hypertension (“PAH”). The compounds described herein can include compounds of Formula (II) and pharmaceutically acceptable salts thereof: wherein the substituents are as described.


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