IDiyas

For the Inventor, By the Inventor

The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12030872 B1

PDFFull Text
Date of Patent:
Jul. 09, 2024

Filed:

Oct. 25, 2019

N-heteroaryl indazole derivatives as lrrk2 inhibitors, pharmaceutical compositions, and uses thereof

Applicant:

Merck Sharp & Dohme Llc, Rahway, NJ (US);

Inventors:

Vladimir Simov, South Boston, MA (US);

William P. Kaplan, Boston, MA (US);

John J. Acton, III, Cranford, NJ (US);

Michael J. Ardolino, Arlington, MA (US);

Joanna L Chen, Braintree, MA (US);

Peter H. Fuller, Ashland, MA (US);

Hakan Gunaydin, Somerville, MA (US);

Derun Li, Roxbury, MA (US);

Ping Liu, Westfield, NJ (US);

Kaitlyn Marie Logan, Boston, MA (US);

Joey Methot, Westwood, MA (US);

Gregori J. Morriello, Randolph, NJ (US);

Santhosh F. Neelamkavil, Edison, NJ (US);

Luis Torres, Norwood, MA (US);

Xin Yan, Newton, MA (US);

Hua Zhou, Acton, MA (US);

Assignee:

Merck Sharp & Dohme LLC, Rahway, NJ (US);

Attorneys:

Sylvia A. Ayler

Catherine D. Fitch

Primary Examiner:

Jeffrey S Lundgren

Assistant Examiner:

Anthony Joseph Seitz

Int. Cl.
CPC ...
C07D 405/14 (2006.01); C07D 401/14 (2006.01); C07D 403/04 (2006.01); C07D 409/14 (2006.01); C07D 413/04 (2006.01); C07D 413/14 (2006.01); C07D 417/04 (2006.01); C07D 417/14 (2006.01);
U.S. Cl.
CPC ...
C07D 405/14 (2013.01); C07D 401/14 (2013.01); C07D 403/04 (2013.01); C07D 409/14 (2013.01); C07D 413/04 (2013.01); C07D 413/14 (2013.01); C07D 417/04 (2013.01); C07D 417/14 (2013.01);
Abstract

The present invention is directed to substituted certain N-heteroaryl indazole derivatives of Formula (I): and pharmaceutically acceptable salts thereof, wherein R, R, R, X, Y, and Z are as defined herein, which are potent inhibitors of LRRK2 kinase and may be useful in the treatment or prevention of diseases in which the LRRK2 kinase is involved, such as Parkinson's Disease and other diseases and disorders described herein. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of diseases, such as Parkinson's disease, in which LRRK-2 kinase is involved.

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