The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 09, 2024
Filed:
Feb. 14, 2020
Bristol-myers Squibb Company, Princeton, NJ (US);
Dean A. Wacker, Yardley, PA (US);
Susheel Jethanand Nara, Mumbai, IN;
Srinivas Cheruku, Bangalore, IN;
Kandhasamy Sarkunam, Hosur, IN;
Firoz Ali Jaipuri, Bengaluru, IN;
Soodamani Thangavel, Krishnagiri, IN;
Rishikesh Narayan, Mumbai, IN;
Subba Reddy Bandreddy, Bangalore, IN;
Srinivas Jogi, Bangalore, IN;
Pavan Kalyan Kathi, Bangalore, IN;
Bristol-Myers Squibb Company, Princeton, NJ (US);
Abstract
Disclosed are compounds of Formula (I) or a stereoisomer, a tautomer, or a pharmaceutically acceptable salt or solvate thereof, wherein Q is a 5-membered heterocyclyl or 5-membered heteroaryl having 1 to 4 heteroatoms independently selected from N, O, and S, substituted with zero to 4 R; and A, X, X, X, X, Z, Z, R, R, R, R, a, b, and d are defined herein. Also disclosed are methods of using these compounds to modulate the activity of farnesoid X receptor (FXR); pharmaceutical compositions comprising these compounds; and methods of treating a disease, disorder, or condition associated with FXR dysregulation, such as pathological fibrosis, transplant rejection, cancer, osteoporosis, and inflammatory disorders, by using the compounds and pharmaceutical compositions.