The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jul. 09, 2024

Filed:

May. 22, 2019
Applicant:

Bio-rad Laboratories, Inc., Hercules, CA (US);

Inventors:

Kalyan Handique, Ann Arbor, MI (US);

Kyle Gleason, Brighton, MI (US);

Austin Payne, Ypsilanti, MI (US);

Priyadarshini Gogoi, Ann Arbor, MI (US);

Christopher Siemer, Ypsilanti, MI (US);

Yi Zhou, Plymouth, MI (US);

Saedeh Javdani Sepehri, Ypsilanti, MI (US);

Assignee:

Bio-Rad Laboratories, Inc., Hercules, CA (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
B01L 3/00 (2006.01); B01L 7/00 (2006.01); G01N 35/00 (2006.01);
U.S. Cl.
CPC ...
B01L 3/502761 (2013.01); B01L 3/502715 (2013.01); B01L 3/527 (2013.01); B01L 3/5635 (2013.01); B01L 7/00 (2013.01); G01N 35/0098 (2013.01); B01L 2200/027 (2013.01); B01L 2200/0647 (2013.01); B01L 2200/0652 (2013.01); B01L 2200/0684 (2013.01); B01L 2300/06 (2013.01); B01L 2300/0816 (2013.01); B01L 2300/0832 (2013.01); B01L 2300/0864 (2013.01); B01L 2300/1822 (2013.01); B01L 2300/1827 (2013.01); B01L 2300/185 (2013.01); B01L 2400/0487 (2013.01); B01L 2400/0683 (2013.01);
Abstract

A system for isolating cells in at least one of single-cell format and single-cluster format, comprising a reservoir, including a reservoir inlet and a reservoir outlet, configured to receive a biological sample and to receive at least one fluid, a manifold configured to receive and deliver the biological sample and the at least one fluid from the reservoir into a biological sample substrate, the manifold comprising a broad surface comprising a central region configured to receive the biological sample substrate, a set of openings configured to enable fluid flow transmission across the biological sample substrate, a manifold inlet configured to transmit flow from the reservoir the first subset of openings, a manifold outlet configured at a downstream end of the broad surface and coupled to the second subset of openings, the manifold outlet configured to transmit waste fluid from the manifold.


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