The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jul. 09, 2024

Filed:

Apr. 10, 2020
Applicants:

The George Washington University, Washington, DC (US);

The United States of America, As Represented BY the Secretary, Department of Health and Human Services, Bethesda, MD (US);

Inventors:

Haitao Cui, Arlington, VA (US);

Lijie Grace Zhang, Ashburn, VA (US);

Yimin Huang, Beijing, CN;

Assignee:

The George Washington University, Washington, DC (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61L 27/38 (2006.01); A61L 27/26 (2006.01); A61L 27/36 (2006.01); B29C 64/106 (2017.01); B29C 64/124 (2017.01); B33Y 10/00 (2015.01); B33Y 70/00 (2020.01); B33Y 80/00 (2015.01); B29K 33/00 (2006.01); B29K 105/00 (2006.01); B29L 31/00 (2006.01);
U.S. Cl.
CPC ...
A61L 27/3625 (2013.01); A61L 27/26 (2013.01); A61L 27/367 (2013.01); A61L 27/3808 (2013.01); A61L 27/3826 (2013.01); A61L 27/3834 (2013.01); A61L 27/3873 (2013.01); B29C 64/106 (2017.08); B29C 64/124 (2017.08); B33Y 10/00 (2014.12); B33Y 70/00 (2014.12); B33Y 80/00 (2014.12); A61L 2430/20 (2013.01); B29K 2033/08 (2013.01); B29K 2089/00 (2013.01); B29K 2105/0088 (2013.01); B29L 2031/7546 (2013.01);
Abstract

A cardiac patch for treatment of a mammalian heart including perfusable vessels embedded integratedly between two layers of anisotropically oriented myocardial fibers. The cardiac patch is made using a dual 3D bioprinting technique using stereolithography to form an anisotropic construct and extrusion printing to form perfusion vessels. A nutrient and oxygen containing media can be provided within the perfusion vessels for growth of cells in the cardiac patch. The technique permits larger patches to be made for the treatment of cardiac damage in both small and large mammalian hearts.


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