The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 09, 2024
Filed:
Jan. 28, 2020
University of Rhode Island Board of Trustees, Kingston, RI (US);
Yale University, New Haven, CT (US);
Yana K. Reshetnyak, Saunderstown, RI (US);
Oleg A. Andreev, Saunderstown, RI (US);
Anna Moshnikova, Warwick, RI (US);
Donald M. Engelman, New Haven, CT (US);
Yale University, New Haven, CT (US);
University of Rhode Island Board of Trustees, Kingston, RI (US);
Abstract
The invention features a composition comprising a potent cytotoxic compound and a pH low insertion peptide, where, e.g., the cytotoxic compound cannot be used alone due to a lack of targeting. The pH low insertion peptide targets cytotoxic compounds to acidic diseased tissue, translocates cytotoxic compounds across plasma membranes into the cytosols of cells in acidic diseased tissues and induces cell death predominantly in the targeted acidic diseased tissue.