The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 02, 2024
Filed:
Mar. 28, 2018
Applicant:
Lyvgen Biopharma Holdings Limited, Grand Cayman, KY;
Inventor:
Jieyi Wang, Belmont, CA (US);
Assignee:
LYVGEN BIOPHARMA HOLDINGS LIMITED, Grand Cayman, KY;
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07K 16/28 (2006.01); A61K 38/18 (2006.01); A61K 39/00 (2006.01); A61P 37/04 (2006.01); C07K 14/705 (2006.01); C07K 16/00 (2006.01);
U.S. Cl.
CPC ...
C07K 16/283 (2013.01); A61K 38/1825 (2013.01); A61P 37/04 (2018.01); A61K 2039/505 (2013.01); C07K 14/70503 (2013.01); C07K 16/00 (2013.01); C07K 2317/50 (2013.01); C07K 2317/52 (2013.01);
Abstract
Human IgG1, IgG2, and IgG4 mutants having mutations in the hinge domain and exhibiting altered binding activity to Fcγ receptors such as FcγRIIB (CD32B). Also provided herein are methods for selectively activating immune responses in a subject using a therapeutic agent capable of targeting both an immune cell surface receptor and FcγRIIB.