The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jul. 02, 2024

Filed:

Nov. 20, 2019
Applicant:

Regeneron Pharmaceuticals, Inc., Tarrytown, NY (US);

Inventors:

Anna Zumsteg, Elmsford, NY (US);

Christos Kyratsous, Irvington, NY (US);

Brinda Prasad, Princeton, NJ (US);

Alida Coppi, Flushing, NY (US);

Assignee:

REGENERON PHARMACEUTICALS, INC., Tarrytown, NY (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07K 16/12 (2006.01); A61K 39/00 (2006.01); A61K 39/40 (2006.01); A61K 45/06 (2006.01); A61P 31/04 (2006.01);
U.S. Cl.
CPC ...
C07K 16/1271 (2013.01); A61K 39/40 (2013.01); A61K 45/06 (2013.01); A61P 31/04 (2018.01); A61K 2039/505 (2013.01); A61K 2039/572 (2013.01); C07K 2317/20 (2013.01); C07K 2317/21 (2013.01); C07K 2317/33 (2013.01); C07K 2317/52 (2013.01); C07K 2317/565 (2013.01); C07K 2317/732 (2013.01); C07K 2317/92 (2013.01); C07K 2317/94 (2013.01);
Abstract

Speciated antibodies or antigen-binding fragments that bind staphylococcal antigens are provided, where the antibodies and antigen-binding fragments have attenuated Fc binding to Protein A or homologous protein. Compositions comprising the antibodies and methods of use are also provided. The antibodies and compositions are useful for treating staphylococcal infection, reducing serum or kidney bacterial titers, and treating symptoms associated with staphylococcal infection. The antibodies may also prevent the severity and/or duration of the primary disease.


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