The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 02, 2024
Filed:
Jan. 22, 2022
University of Kansas, Lawrence, KS (US);
Mark Patrick Farrell, Lawrence, KS (US);
Suresh Eknath Kurhade, Lawrence, KS (US);
Patrick Andrew Ross, Lawrence, KS (US);
Jack Douglas Weiner, Overland Park, KS (US);
Fei Philip Gao, Lawrence, KS (US);
UNIVERSITY OF KANSAS, Lawrence, KS (US);
Abstract
The present disclosure relates to compounds according to Formula I (I) or a pharmaceutically acceptable salt and/or solvate thereof, as well as compositions including such compounds and uses thereof, where Ris an unsubstituted C-Calkyl; and R, R, and Rare each independently H or —C(O)—(unsubstituted C-Calkyl). Among other things, the present disclosure evidences that the significant upregulation of CD20 by the inhibition of a-mannosidase enzymes by compounds of the present technology potentiates the activity of anti-CD20 mAbs and importantly sensitize cell lines that are resistant to the action of these antibodies.