The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jul. 02, 2024

Filed:

Sep. 25, 2020
Applicant:

Daebong Ls Co., Ltd., Incheon, KR;

Inventors:

Eun Ju Park, Hwaseong-si, KR;

Hyun Ji, Siheung-si, KR;

Ji Eun Lee, Busan, KR;

Jin Oh Park, Seoul, KR;

Assignee:

DAEBONG LS CO., LTD., Incheon, KR;

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/454 (2006.01); A61K 9/16 (2006.01); C07D 401/06 (2006.01);
U.S. Cl.
CPC ...
A61K 9/1652 (2013.01); A61K 9/1635 (2013.01); C07D 401/06 (2013.01); C07B 2200/13 (2013.01);
Abstract

A solid dispersion of amorphous efinaconazole and a method for preparing the same are proposed. The solid dispersion includes an amorphous form of efinaconazole and at least one stabilization carrier selected from hydroxypropyl methylcellulose (HPMC), hydroxypropyl cellulose (HPC), ethyl cellulose (EC), hydroxypropyl methylcellulose acetate succinate (HPMC-AS), polyvinylpyrrolidone (PVP), polyacrylic acid (PAA), saccharin, and malonic acid. The solid dispersion undergoes minimal thermodynamic deformation when exposed to ambient temperature and humidity, achieving improved stability, while maintaining the inherent improved stability and bioavailability of amorphous efinaconazole.


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