The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 02, 2024
Filed:
Oct. 29, 2019
Applicant:
Hoffmann-la Roche Inc., Little Falls, NJ (US);
Inventors:
Joerg Benz, Rheinfelden, DE;
Ulrich Brinkmann, Weilheim, DE;
Stefan Dengl, Munich, DE;
Sebastian Dziadek, Benediktbeuern, DE;
Guy Georges, Habach, DE;
Michael Grote, Penzberg, DE;
Alexander Haas, Munich, DE;
Eike Hoffmann, Herrsching a. Ammersee, DE;
Assignee:
Hoffmann-La Roche Inc., Nutley, NJ (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/385 (2006.01); A61K 39/00 (2006.01); A61K 47/68 (2017.01); B82Y 5/00 (2011.01); C07K 16/00 (2006.01); C07K 16/16 (2006.01); C07K 16/28 (2006.01); C07K 16/40 (2006.01); C07K 16/44 (2006.01); C07K 16/46 (2006.01); G01N 33/68 (2006.01);
U.S. Cl.
CPC ...
A61K 39/385 (2013.01); A61K 47/6835 (2017.08); A61K 47/6879 (2017.08); A61K 47/6897 (2017.08); B82Y 5/00 (2013.01); C07K 16/00 (2013.01); C07K 16/16 (2013.01); C07K 16/2896 (2013.01); C07K 16/40 (2013.01); C07K 16/44 (2013.01); C07K 16/468 (2013.01); G01N 33/6857 (2013.01); A61K 2039/6056 (2013.01); A61K 2039/627 (2013.01); C07K 2317/24 (2013.01); C07K 2317/31 (2013.01); C07K 2317/40 (2013.01); C07K 2317/55 (2013.01); C07K 2317/565 (2013.01); C07K 2317/624 (2013.01); C07K 2317/94 (2013.01);
Abstract
Herein is reported a conjugate comprising an antigen and an antibody that specifically binds to the antigen wherein a covalent bond is formed between the antigen and an amino acid residue in the CDR2 of the antibody, an antibody comprising a cysteine residue at amino acid position 53 (according to Kabat) in the heavy chain CDR2 and uses thereof.