The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 02, 2024
Filed:
Oct. 22, 2021
Applicant:
AF Chemicals, Llc, San Diego, CA (US);
Inventor:
Michael Kelner, San Diego, CA (US);
Assignee:
AF Chemicals, LLC, San Diego, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/5375 (2006.01); A61K 31/047 (2006.01); A61K 31/121 (2006.01); A61K 31/122 (2006.01); A61K 31/135 (2006.01); A61K 31/15 (2006.01); A61K 31/16 (2006.01); A61K 31/18 (2006.01); A61K 31/192 (2006.01); A61K 31/198 (2006.01); A61K 31/351 (2006.01); A61K 31/357 (2006.01); A61K 31/401 (2006.01); C12Q 1/6886 (2018.01);
U.S. Cl.
CPC ...
A61K 31/5375 (2013.01); A61K 31/047 (2013.01); A61K 31/121 (2013.01); A61K 31/122 (2013.01); A61K 31/135 (2013.01); A61K 31/15 (2013.01); A61K 31/16 (2013.01); A61K 31/18 (2013.01); A61K 31/192 (2013.01); A61K 31/198 (2013.01); A61K 31/351 (2013.01); A61K 31/357 (2013.01); A61K 31/401 (2013.01); C12Q 1/6886 (2013.01); C12Q 2600/158 (2013.01); C12Q 2600/16 (2013.01);
Abstract
In an embodiment of the invention, a method of treating cancer includes screening to select a patient population that will respond to an Illudofulvene Analog composition based on the presence of one or more Transcription Coupled Repair (TCR) mutations, deletions or other events interfering with TCR biomarker expression in combination with upregulation of Myc and/or PTGR biomarker expression and treating the patient population with the Illudofulvene Analog composition.