The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jul. 02, 2024

Filed:

Jul. 29, 2020
Applicant:

United Therapeutics Corporation, Silver Spring, MD (US);

Inventors:

Ryan Bonvillain, Cary, NC (US);

John Cheadle, Durham, NC (US);

Thomas Petersen, Durham, NC (US);

Assignee:

United Therapeutics Corporation, Silver Spring, MD (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A01N 1/02 (2006.01); A61L 2/00 (2006.01); A61L 27/36 (2006.01); G01G 19/00 (2006.01); G01K 13/02 (2021.01); G01L 7/00 (2006.01);
U.S. Cl.
CPC ...
A01N 1/0247 (2013.01); A61L 2/0017 (2013.01); A61L 27/36 (2013.01); G01G 19/00 (2013.01); G01K 13/02 (2013.01); G01L 7/00 (2013.01);
Abstract

An automated bioreactor system for decellularizing an organ includes a main chamber for containing the organ. The system further includes a reagent chamber containing a liquid phase reagent. A reagent conduit delivers the liquid phase reagent to the main chamber, and a perfusion conduit delivers the reagent from the reagent outlet in the main chamber into the organ. A perfusion pump drives the flow of the reagent. A perfusion pressure sensor detects a pressure of the flowing reagent. A control system controls the perfusion pump to drive the flow of the reagent based on a received input representative of a desired pressure and a received input of the detected pressure. The control system may automatically perform all of the steps of a decellularization protocol based on sensor input. An automated waste decontamination system may also be provided.


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