Interferometry based systems to detect small mass changes of an object in a solution

Abstract

A computer-implemented method of using interferometry to detect mass changes of objects in a solution includes obtaining a time series of images using interferometry, and performing background correction on each image by classifying pixels of the image as background pixels or object pixels, fitting only the background pixels of the image to a function to generate a background fitted function, and subtracting the background fitted function from the image to generate a background corrected image. The method includes performing segmentation on the background corrected images to resolve boundaries of one or more objects, performing motion tracking on the objects to track changes in position of the objects, determining respective masses of the motion tracked objects and determining, for each image in the time series, an aggregate mass based on the respective masses to determine whether the aggregate mass of the motion tracked objects is increasing or decreasing.