The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 25, 2024
Filed:
Apr. 09, 2020
Applicant:
Ultragenyx Pharmaceutical Inc., Novato, CA (US);
Inventors:
Aubrey R. Tiernan, Somerville, MA (US);
Nicholas Richards, Arlington, MA (US);
Assignee:
Ultragenyx Pharmaceutical Inc., Novato, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07H 21/04 (2006.01); C12N 7/00 (2006.01); C12N 15/11 (2006.01); C12N 15/86 (2006.01); C12Q 1/6869 (2018.01);
U.S. Cl.
CPC ...
C12N 7/00 (2013.01); C12N 15/11 (2013.01); C12N 15/86 (2013.01); C12Q 1/6869 (2013.01); C12N 2310/14 (2013.01); C12N 2310/315 (2013.01); C12N 2310/321 (2013.01); C12N 2750/14143 (2013.01); C12N 2750/14152 (2013.01);
Abstract
This application relates to recombinant adeno-associated virus (rAAV) packaging and/or producer cell lines which have been engineered to reduce expression and/or activity of one or more genes and/or proteins to increase rAAV titers. The methods of generating the engineered cell lines have also been described herein.