The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 25, 2024
Filed:
Jan. 24, 2019
Kataoka Corporation, Kyoto, JP;
Kyoto Prefectural Public University Corporation, Kyoto, JP;
Ping Dai, Kyoto, JP;
Yukimasa Takeda, Kyoto, JP;
Yoshinori Harada, Kyoto, JP;
Junichi Matsumoto, Kyoto, JP;
Ayumi Kusaka, Kyoto, JP;
KATAOKA CORPORATION, Kyoto, JP;
KYOTO PREFECTURAL PUBLIC UNIVERSITY CORPORATION, Kyoto, JP;
Abstract
The present invention chiefly aims to provide a process for directly inducing insulin-producing cells from somatic cells without performing artificial gene transfer. The present invention can include a process for producing an insulin-producing cell by inducing differentiation directly from a somatic cell, the process comprising a step of culturing the somatic cell in the presence of a cAMP inducer, and six members selected from the group consisting of a GSK3 inhibitor, a TGF-β inhibitor, a BMP inhibitor, a p53 inhibitor, a PI3K inhibitor, a Notch inhibitor and a RAR agonist, or all members thereof. The insulin-producing cells obtained by the present invention are useful in regenerative medicine and the like.