The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jun. 25, 2024

Filed:

Apr. 12, 2022
Applicant:

Cephalon Llc, West Chester, PA (US);

Inventors:

Doris Shim Siew Chen, Yagoona, AU;

Lynn Dorothy Poulton, Macquarie Park, AU;

Adam Clarke, Macquarie Park, AU;

David Jose Simon Laine, Macquarie Park, AU;

Matthew Pollard, Macquarie Park, AU;

Bridget Ann Cooksey, Macquarie Park, AU;

Anthony Doyle, Macquarie Park, AU;

Jason William Gill, Macquarie Park, AU;

Assignee:

Cephalon LLC, West Chester, PA (US);

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 39/395 (2006.01); A61P 11/00 (2006.01); C07K 16/28 (2006.01); G01N 33/53 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
C07K 16/2866 (2013.01); A61P 11/00 (2018.01); A61K 39/395 (2013.01); A61K 2039/505 (2013.01); C07K 2317/21 (2013.01); C07K 2317/76 (2013.01); C07K 2317/92 (2013.01); G01N 33/53 (2013.01);
Abstract

Disclosed herein are human antibody molecules that immunospecifically bind to human CXCR2. The disclosed human antibody molecules are potent and selective antagonists of CXCR2 functions and prevent the recruitment of neutrophils into tissues without strongly depleting circulating neutrophil numbers. Pharmaceutical compositions, nucleic acid molecules, vectors, cells, and uses of the disclosed antibodies are also provided.


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