The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 25, 2024
Filed:
Dec. 12, 2019
Applicant:
Rappaport Family Institute for Research IN the Medical Sciences, Haifa, IL;
Inventor:
Yuval Shaked, Binyamina, IL;
Assignee:
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
G16H 20/10 (2018.01); A61K 31/38 (2006.01); A61K 38/17 (2006.01); A61P 35/00 (2006.01); C07K 16/22 (2006.01); C07K 16/28 (2006.01); G16B 15/20 (2019.01); A61K 45/06 (2006.01);
U.S. Cl.
CPC ...
A61K 38/1774 (2013.01); A61K 31/38 (2013.01); A61P 35/00 (2018.01); C07K 16/22 (2013.01); C07K 16/2818 (2013.01); C07K 16/2827 (2013.01); G16B 15/20 (2019.02); G16H 20/10 (2018.01); A61K 45/06 (2013.01);
Abstract
A method is provided for treating a cancer patient non-responsive to treatment with a immune checkpoint inhibitor (ICI) by treating the patient with said ICI in combination with an agent that blocks the activity of a dominant factor selected among the plurality of host-driven resistance factors generated in response to treatment of the cancer patient with the ICI, these factors having a fold-change predictive of a non-favorable response of the cancer patient to the treatment with the ICI.