The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 25, 2024
Filed:
Aug. 09, 2021
Applicant:
New York University, New York, NY (US);
Inventors:
Dafna Bar-Sagi, New York, NY (US);
Jane Cullis, New York, NY (US);
Craig Ramirez, Short Hills, NJ (US);
Assignee:
NEW YORK UNIVERSITY, New York, NY (US);
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/38 (2006.01); A61K 31/337 (2006.01); A61K 35/15 (2015.01); A61K 38/00 (2006.01); A61K 38/18 (2006.01); A61K 38/19 (2006.01); A61K 38/20 (2006.01); A61P 35/00 (2006.01); C07K 14/52 (2006.01); C07K 14/53 (2006.01); C07K 14/54 (2006.01); C07K 14/76 (2006.01); C07K 14/765 (2006.01); C12N 5/0786 (2010.01);
U.S. Cl.
CPC ...
A61K 35/15 (2013.01); A61K 31/337 (2013.01); A61K 38/00 (2013.01); A61K 38/18 (2013.01); A61K 38/19 (2013.01); A61K 38/193 (2013.01); A61K 38/20 (2013.01); A61K 38/2006 (2013.01); A61K 38/2026 (2013.01); A61K 38/2066 (2013.01); A61K 38/385 (2013.01); A61P 35/00 (2018.01); C07K 14/52 (2013.01); C07K 14/53 (2013.01); C07K 14/54 (2013.01); C07K 14/5406 (2013.01); C07K 14/5428 (2013.01); C07K 14/76 (2013.01); C07K 14/765 (2013.01); C12N 5/0645 (2013.01); C12N 2501/22 (2013.01); C12N 2501/2301 (2013.01); C12N 2501/2304 (2013.01); C12N 2501/2306 (2013.01); C12N 2501/231 (2013.01); C12N 2501/2333 (2013.01); C12N 2501/24 (2013.01); C12N 2501/25 (2013.01);
Abstract
The present invention is directed to methods of inducing a phenotypic change in a population of monocytes and/or macrophages. The method includes administering to the population of monocytes and/or macrophages, a macrophage stimulating agent coupled to a carrier molecule, wherein the carrier molecule facilitates macropinocytic uptake of the agent by monocytes and macrophages in the population and is defective in neonatal Fc receptor binding, wherein the administering induces a phenotypic change in the monocytes and macrophages in the population.