The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 18, 2024
Filed:
Dec. 09, 2021
Manus Bio Inc., Cambridge, MA (US);
Ajikumar Parayil Kumaran, Watertown, MA (US);
Christine Nicole S. Santos, Newton, MA (US);
Jason Eric Donald, Lexington, MA (US);
Mary Elizabeth Fowler, Somerville, MA (US);
Ryan N. Philippe, Somerville, MA (US);
Christopher Scott Frei, Weymouth, MA (US);
Aaron Love, Boston, MA (US);
Manus Bio Inc., Cambridge, MA (US);
Abstract
In various aspects and embodiments, the invention provides microbial cells and methods for producing advanced glycosylation products from lower glycosylated intermediates. The microbial cell expresses one or more UDP-dependent glycosyl transferase enzymes in the cytoplasm, for glycosylation of the intermediates. When incubating the microbial strain with a plant extract or fraction thereof comprising the intermediates, these glycosylated intermediates are available for further glycosylation by the cell, and the advanced glycosylation products can be recovered from the media and/or microbial cells.