The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 18, 2024
Filed:
Jul. 01, 2021
Applicant:
Massachusetts Institute of Technology, Cambridge, MA (US);
Inventors:
Omar Abudayyeh, Cambridge, MA (US);
Jonathan Gootenberg, Cambridge, MA (US);
Assignee:
Massachusetts Institute of Technology, Cambridge, MA (US);
Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12N 9/22 (2006.01); A61K 38/00 (2006.01); A61K 48/00 (2006.01); C12N 9/78 (2006.01); C12N 15/10 (2006.01); C12N 15/11 (2006.01); C12N 15/63 (2006.01); C12Q 1/6825 (2018.01);
U.S. Cl.
CPC ...
C12N 9/22 (2013.01); A61K 48/005 (2013.01); C12N 9/78 (2013.01); C12N 15/102 (2013.01); C12N 15/11 (2013.01); C12N 15/63 (2013.01); C12Y 305/04004 (2013.01); C12Y 305/04005 (2013.01); A61K 38/00 (2013.01); C07K 2319/85 (2013.01); C12N 2310/20 (2017.05); C12N 2320/10 (2013.01); C12N 2320/33 (2013.01); C12Q 1/6825 (2013.01);
Abstract
This disclosure provides systems, methods, and compositions for RNA-guided RNA-targeting CRISPR effectors for the treatment of diseases as well as diagnostics. In some embodiments, nucleotide deaminase functionalized CRISPR systems for RNA editing RNA knockdown, viral resistance, splicing modulation, RNA tracking, translation modulation, and epi-transcriptomic modifications are disclosed.