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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12012598 B1

PDFFull Text
Date of Patent:
Jun. 18, 2024

Filed:

Aug. 14, 2017

Manipulated immunoregulatory element and immunity altered thereby

Applicant:

Toolgen Incorporated, Seoul, KR;

Inventors:

Seok Joong Kim, Seoul, KR;

Yoon-Young Kim, Seoul, KR;

Ho-Sung Yu, Gyeonggi-do, KR;

In-Young Jung, Gyeonggi-do, KR;

Jung Min Lee, Seoul, KR;

Assignee:

TOOLGEN INCORPORATED, Seoul, KR;

Attorney:

Harness, Dickey & Pierce, P.L.C.

Primary Examiner:

Quang Nguyen

Int. Cl.
CPC ...
C12N 15/113 (2010.01); A61K 35/14 (2015.01); C07K 1/00 (2006.01); C07K 14/705 (2006.01); C12N 5/0783 (2010.01); C12N 5/0784 (2010.01); C12N 15/10 (2006.01); C12N 15/52 (2006.01); C12N 15/63 (2006.01); C12N 15/85 (2006.01); A61K 31/70 (2006.01); C12N 9/22 (2006.01);
U.S. Cl.
CPC ...
C12N 15/1132 (2013.01); A61K 35/14 (2013.01); C07K 14/70503 (2013.01); C07K 14/70564 (2013.01); C07K 14/70575 (2013.01); C07K 14/70578 (2013.01); C07K 14/70596 (2013.01); C12N 5/0637 (2013.01); C12N 5/0638 (2013.01); C12N 5/064 (2013.01); C12N 5/0646 (2013.01); C12N 15/102 (2013.01); C12N 15/1138 (2013.01); C12N 15/52 (2013.01); C12N 15/63 (2013.01); C12N 15/85 (2013.01); C12N 9/22 (2013.01); C12N 2310/20 (2017.05); C12N 2320/30 (2013.01); Y02A 50/30 (2018.01);
Abstract

The present invention relates to an artificially manipulated immune system having an improved immune effect. More particularly, the present invention relates to an immune system having functions artificially altered which comprises artificially manipulated immunoregulatory elements and cells containing the same. Contemplated according to a particular embodiment is an immune system comprising artificially manipulated immunoregulatory genes such as PD-1, CTLA-4, A20, DGKα, DGKζ, FAS, EGR2, PPP2R2D, PSGL-1, KDM6A, and TET2, and/or expression products thereof.

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