The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 18, 2024
Filed:
Jul. 16, 2021
Applicant:
Guerbet, Villepinte, FR;
Inventors:
Jean-Michel Paratian, La Rochelle, FR;
Martine Cerf, Breuil-Magné, FR;
Assignee:
GUERBET, Villepinte, FR;
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07C 69/63 (2006.01); C07C 67/08 (2006.01); C07C 67/307 (2006.01); C07C 67/54 (2006.01); C07D 307/33 (2006.01);
U.S. Cl.
CPC ...
C07C 69/63 (2013.01); C07C 67/08 (2013.01); C07C 67/307 (2013.01); C07C 67/54 (2013.01); C07D 307/33 (2013.01);
Abstract
The present invention relates to a process for preparing the 2-bromoglutaric acid diester of formula (I) below: comprising the formation of the 2-hydroxyglutaric acid diester of formula (II) by reaction of butyrolactone acid of formula (BA) with the alcohol of formula ROH, in the presence of an acid such as sulfuric acid; and bromination of the 2-hydroxyglutaric acid diester of formula (II), by sparging with gaseous hydrobromic acid. The present invention also relates to a 2-bromoglutaric acid diester of formula (I), having a degree of purity determined by HPLC analysis of greater than or equal to 90%.