The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 18, 2024
Filed:
Jun. 04, 2020
Immatics Us, Inc., Houston, TX (US);
Immatics Biotechnologies Gmbh, Tübingen, DE;
Amir Alpert, Houston, TX (US);
Dominik Maurer, Moessingen, DE;
Anastasiya Smith, Houston, TX (US);
Claudia Wagner, Tuebingen, DE;
Ali Mohamed, Sugar Land, TX (US);
IMMATICS US, INC., Houston, TX (US);
IMMATICS BIOTECHNOLOGIES GMBH, Tübingen, DE;
Abstract
Described herein are methods for preparing T cells, including isolating CD8+ T cells from a blood sample obtained from a patient or a donor, culturing the isolated CD8+ T cells in the presence of at least one cytokine, contacting the cultured CD8+ T cells with a multimer containing a target peptide in a complex with an MHC molecule and with at least one binding agent that binds to a T cell surface molecule, in which the multimer is labelled with a first detectable agent and the binding agent is labelled with a second detectable agent, sorting the contacted CD8+ T cells to collect the sorted CD8+ T cells that are detected positive for the first and the second detectable agents, and expanding the collected CD8+ T cells.