The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 18, 2024
Filed:
Aug. 21, 2019
The Usa, As Represented BY the Secretary, Dept. of Health and Human Services, Bethesda, MD (US);
THE USA, AS REPRESENTED BY THE SECRETARY, DEPT. OF HEALTH AND HUMAN SERVICES, Bethesda, MD (US);
Abstract
Methods are disclosed for treating and/or preventing a neurological condition, such as neural injury or neurological disorder, in a subject through metabolic regulation of mitochondria using compounds that are natural metabolites, metabolite analogs, or derivatives of natural metabolites to modulate biochemical pathways comprising succinate and/or succinate dehydrogenase, thereby reducing microglial cell and/or astrocyte activation. Compounds and related formulations are also provided to modulate the biochemical pathways comprising succinate and/or succinate dehydrogenase for reducing or inhibiting microglial cell and/or astrocyte activation.