The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 11, 2024
Filed:
May. 14, 2020
Applicant:
Genentech, Inc., South San Francisco, CA (US);
Inventor:
Kendall Carey, South San Francisco, CA (US);
Assignee:
GENENTECH, INC., South San Francisco, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/00 (2006.01); C07K 16/28 (2006.01); G01N 33/50 (2006.01); G01N 33/567 (2006.01); G01N 33/68 (2006.01);
U.S. Cl.
CPC ...
G01N 33/6854 (2013.01); C07K 16/2809 (2013.01); C07K 16/2887 (2013.01); G01N 33/505 (2013.01); C07K 2317/31 (2013.01); C07K 2317/56 (2013.01); C07K 2317/92 (2013.01); G01N 33/6845 (2013.01);
Abstract
The present invention provides a cell-based assay for identifying and/or quantifying anti-CD3 homodimers in a composition comprising a T cell-dependent Bispecific antibody (TDB). In some aspects, the invention T cells comprising a T cell activation responsive reporter are contacted with the TDB to detect the presence of anti-CD3 homodimers. Compositions of reporter T cells and kits are also contemplated.