The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 11, 2024
Filed:
Aug. 12, 2021
Applicant:
University of South Carolina, Columbia, SC (US);
Inventors:
Wenbin Tan, Columbia, SC (US);
Elaine G. Taine, Columbia, SC (US);
Hui Wang, Wuhan, CN;
Vi Nguyen, Columbia, SC (US);
Xiaoling Cao, Columbia, SC (US);
Assignee:
University of South Carolina, Columbia, SC (US);
Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12Q 1/6883 (2018.01); C07K 16/28 (2006.01);
U.S. Cl.
CPC ...
C12Q 1/6883 (2013.01); C07K 16/2896 (2013.01); C07K 2317/76 (2013.01); C12Q 2600/158 (2013.01);
Abstract
Described herein are methods and systems using ADAM30 as a biomarker to help early diagnosis of congenital malformed vasculatures in children and which can also serve as a companion diagnostic biomarker for malformed vasculatures, as well as a subpopulation of cancer cells, wherein blockage of activity of ADAM30 by a neutralized antibody or inhibitor can be used as a treatment strategy for those ADAM30-positive vascular endothelial cells and cancer cells.