The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jun. 11, 2024

Filed:

Sep. 16, 2022
Applicant:

University of Washington, Seattle, WA (US);

Inventors:

Scott R. Kennedy, Seattle, WA (US);

Jesse J. Salk, Seattle, WA (US);

Michael Hipp, Seattle, WA (US);

Elizabeth Schmidt, Seattle, WA (US);

Rosa Ana Risques, Seattle, WA (US);

Daniela Nachmanson, Seattle, WA (US);

Assignee:

UNIVERSITY OF WASHINGTON, Seattle, WA (US);

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12Q 1/6806 (2018.01); C12Q 1/6855 (2018.01); C12Q 1/686 (2018.01);
U.S. Cl.
CPC ...
C12Q 1/6806 (2013.01); C12Q 1/6855 (2013.01); C12Q 1/686 (2013.01); C12Q 2521/501 (2013.01); C12Q 2525/191 (2013.01); C12Q 2531/113 (2013.01); C12Q 2535/119 (2013.01); C12Q 2535/122 (2013.01);
Abstract

The present technology relates generally to methods and compositions for targeted nucleic acid sequence enrichment, as well as uses of such enrichment for error-corrected nucleic acid sequencing applications. In some embodiments, highly accurate, error corrected and massively parallel sequencing of nucleic acid material is possible using a combination of uniquely labeled strands in a double-stranded nucleic acid complex in such a way that each strand can be informatically related to its complementary strand, but also distinguished from it following sequencing of each strand or an amplified product derived therefrom. In various embodiments, this information can be used for the purpose of error correction of the determined sequence.


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