The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 11, 2024
Filed:
Jun. 09, 2020
Applicant:
Purdue Research Foundation, West Lafayette, IN (US);
Inventors:
Sophie Andree Lelievre, West Lafayette, IN (US);
Rahim Rahimi, West Lafayette, IN (US);
Tim Kwok, Philadelphia, PA (US);
Assignee:
Purdue Research Foundation, West Lafayette, IN (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12N 5/00 (2006.01); C12M 1/12 (2006.01); C12N 5/09 (2010.01);
U.S. Cl.
CPC ...
C12N 5/0068 (2013.01); C12M 25/14 (2013.01); C12N 5/0062 (2013.01); C12N 5/0693 (2013.01); C12N 2533/30 (2013.01); C12N 2533/52 (2013.01); C12N 2533/54 (2013.01); C12N 2533/80 (2013.01);
Abstract
A collagen-fibronectin-based method enables the production of tumors of centimeter size with recognizable pathological traits. The method supports reproducing tumor heterogeneity with preinvasive and invasive phenotypes and stacking of tumor portions using a paper-scaffold with 80 μm-punched holes for larger nodule creation and easy separation of tumor portions for analysis. Macrotumors are convenient for testing drug delivery and therapeutic tools that necessitate a minimum tumor size relevant to in vivo.