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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12006372 B1

PDFFull Text
Date of Patent:
Jun. 11, 2024

Filed:

Jun. 28, 2021

Anti-garp antibody

Applicant:

Daiichi Sankyo Company, Limited, Tokyo, JP;

Inventors:

Kazuki Satoh, Tokyo, JP;

Kazuki Hirahara, Tokyo, JP;

Ichiro Watanabe, Tokyo, JP;

Masato Amano, Tokyo, JP;

Assignee:

DAIICHI SANKYO COMPANY, LIMITED, Tokyo, JP;

Attorney:

Foley & Lardner LLP

Primary Examiner:

Hong Sang

Int. Cl.
CPC ...
C07K 16/28 (2006.01); A61K 39/395 (2006.01); C07K 16/32 (2006.01); C12N 1/20 (2006.01); C12N 5/10 (2006.01); C12N 5/12 (2006.01); C12N 15/02 (2006.01); A61K 39/00 (2006.01); A61P 35/00 (2006.01);
U.S. Cl.
CPC ...
C07K 16/32 (2013.01); A61K 39/395 (2013.01); C07K 16/28 (2013.01); C12N 1/20 (2013.01); C12N 5/10 (2013.01); C12N 5/12 (2013.01); C12N 15/02 (2013.01); A61K 2039/505 (2013.01); A61P 35/00 (2018.01); C07K 2317/51 (2013.01); C07K 2317/515 (2013.01); C07K 2317/565 (2013.01); C07K 2317/732 (2013.01); C07K 2317/92 (2013.01);
Abstract

The present invention relates to an antibody that binds to GARP and is useful as a therapeutic agent for a tumor, and a method for treating a tumor using the aforementioned antibody. It is an object of the present invention to provide an antibody, which inhibits the function of Treg in a tumor and is thereby used as a pharmaceutical product having therapeutic effects, a method for treating a tumor using the aforementioned antibody, and the like. An anti-GARP antibody that binds to GARP and exhibits inhibitory activity to Treg function and exhibits ADCC activity is obtained, and moreover a pharmaceutical composition for use in tumor therapy, comprising the aforementioned antibody, etc. is obtained.

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