The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 11, 2024
Filed:
Jun. 11, 2021
Applicant:
Provention Bio, Inc., Red Bank, NJ (US);
Inventors:
Francisco Leon, Bethesda, MD (US);
Kevan C. Herold, Norwalk, CT (US);
Sarah Alice Long, Seattle, WA (US);
Peter S. Linsley, Seattle, WA (US);
Primary Examiner:
Int. Cl.
CPC ...
C07K 16/28 (2006.01); A61P 3/10 (2006.01); G01N 33/68 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
C07K 16/2809 (2013.01); A61P 3/10 (2018.01); G01N 33/6854 (2013.01); A61K 2039/505 (2013.01); A61K 2039/545 (2013.01); G01N 2800/52 (2013.01);
Abstract
Provided herein, in one aspect, is a method of preventing or delaying the onset of clinical type 1 diabetes (T1D), comprising: providing a non-diabetic subject who is at risk for T1D; administering a prophylactically effective amount of an anti-CD3 antibody to the non-diabetic subject; and determining, prior to or after the administering step, that the non-diabetic subject has more than about 5% to more than about 10% TIGIT+KLRG1+CD8+ T-cells in all CD3+ T cells, which is indicative of successful prevention or delay of the onset of clinical T1D.