The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 11, 2024
Filed:
Apr. 28, 2020
Genentech, Inc., South San Francisco, CA (US);
Germaine Fuh, Pacifica, CA (US);
Chingwei V. Lee, Foster City, CA (US);
Patrick Koenig, San Francisco, CA (US);
Genentech, Inc., South San Francisco, CA (US);
Abstract
The invention provides dual specific antibodies capable of binding interleukin 4 (IL4) and interleukin 5 (IL5) and methods of making and using such antibodies. In general, the dual specific antibodies capable of binding IL4 and IL5 are generated by identification of a monospecific antibody having light chain variable region Vresidues that are electrostatic or hydrophobic and altering the nucleic acid sequence encoding one or more solvent accessible residues in the Vof the antibody either alone or in combination with alteration of the nucleic acid sequence encoding the Vof the antibody. The altered Vand the Vare expressed and dual specific antibodies, or antigen-binding fragments thereof, are selected.