The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 11, 2024
Filed:
Jul. 13, 2022
Applicant:
Washington University, St. Louis, MO (US);
Inventors:
Michael J. Holtzman, St. Louis, MO (US);
Arthur G. Romero, Chesterfield, MO (US);
Benjamin J. Gerovac, St. Louis, MO (US);
Zhenfu Han, St. Louis, MO (US);
Shamus P. Keeler, University City, MO (US);
Kangyun Wu, St. Louis, MO (US);
Yong Zhang, St. Louis, MO (US);
Assignee:
WASHINGTON UNIVERSITY, St. Louis, MO (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 417/06 (2006.01); C07D 213/75 (2006.01); C07F 7/08 (2006.01);
U.S. Cl.
CPC ...
C07F 7/0812 (2013.01); C07D 213/75 (2013.01);
Abstract
Compounds that inhibit mitogen-activated protein kinases (MAPKs) are disclosed. Some inhibitor compounds specifically target a single MAPK such as MAPK13, while others target multiple MAPKs such as MAPK13 and MAPK12. The compounds can be used therapeutically for a variety of diseases, including cancer and respiratory diseases. Methods of synthesis of the compounds are also disclosed.