The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 11, 2024
Filed:
Aug. 17, 2021
Applicant:
Battelle Memorial Institute, Richland, WA (US);
Inventors:
Ryan T. Kelly, West Richland, WA (US);
Ying Zhu, Richland, WA (US);
Richard D. Smith, Richland, WA (US);
Assignee:
BATTELLE MEMORIAL INSTITUTE, Richland, WA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
B01L 3/00 (2006.01); A61B 10/02 (2006.01); B01J 19/00 (2006.01); C12M 1/00 (2006.01); C12M 1/34 (2006.01); C12Q 1/6881 (2018.01); C40B 60/04 (2006.01); G01N 1/28 (2006.01); G01N 1/30 (2006.01); G01N 1/34 (2006.01); G01N 30/88 (2006.01); G01N 33/483 (2006.01); G01N 33/68 (2006.01); G02B 21/32 (2006.01);
U.S. Cl.
CPC ...
B01L 3/502753 (2013.01); A61B 10/02 (2013.01); B01J 19/0046 (2013.01); B01L 3/00 (2013.01); B01L 3/50853 (2013.01); B01L 3/5088 (2013.01); C12M 23/58 (2013.01); C12M 41/00 (2013.01); C12Q 1/6881 (2013.01); C40B 60/04 (2013.01); G01N 1/2813 (2013.01); G01N 1/30 (2013.01); G01N 1/34 (2013.01); G01N 30/88 (2013.01); G01N 33/4833 (2013.01); G01N 33/68 (2013.01); G02B 21/32 (2013.01); B01J 2219/00317 (2013.01); B01J 2219/00367 (2013.01); B01J 2219/00619 (2013.01); B01J 2219/00621 (2013.01); B01J 2219/00659 (2013.01); B01J 2219/00702 (2013.01); B01J 2219/00725 (2013.01); B01J 2219/00743 (2013.01); B01L 2200/142 (2013.01); B01L 2300/0819 (2013.01); B01L 2300/0822 (2013.01); B01L 2300/0887 (2013.01); G01N 2001/284 (2013.01); G01N 2030/8831 (2013.01);
Abstract
Provided herein are methods and systems for biochemical analysis, including compositions and methods for processing and analysis of small cell populations and biological samples (e.g., a robotically controlled chip-based nanodroplet platform). In particular aspects, the methods described herein can reduce total processing volumes from conventional volumes to nanoliter volumes within a single reactor vessel (e.g., within a single droplet reactor) while minimizing losses, such as due to sample evaporation.