The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 11, 2024
Filed:
Aug. 06, 2020
The Rockefeller University, New York, NY (US);
Rensselaer Polytechnic Institute, Troy, NY (US);
Sarah Stanley, Berkeley, CA (US);
Jeffrey Friedman, New York, NY (US);
Jonathan S. Dordick, Schenectady, NY (US);
Jeremy Sauer, Princeton, NJ (US);
THE ROCKEFELLER UNIVERSITY, New York, NY (US);
RENSSELAER POLYTECHNIC INSTITUTE, Troy, NY (US);
Abstract
The present invention provides methods and compositions for the remote control of cell function based on the use of a magnetic field to excite paramagnetic nanoparticles targeted to specific cell types. The cell type of interest expresses an ion channel wherein excitation of the paramagnetic nanoparticles results in a physical change that is transduced into a cellular response. Such cellular responses may include, for example, increases in gene expression resulting in production of one or more physiologically active proteins. The expression of such proteins can be used to treat a variety of different inherited or acquired diseases or disorders in a subject.