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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12005156 B1

PDFFull Text
Date of Patent:
Jun. 11, 2024

Filed:

Apr. 02, 2021

Berberine/mineralized collagen-based composite membrane and preparation method and application thereof

Applicant:

Weifang Medical University, Shandong, CN;

Inventors:

Weifen Zhang, Shandong, CN;

Jian Zhang, Shandong, CN;

Jingjing Zhang, Shandong, CN;

Dejun Ding, Shandong, CN;

Xiuwen Guan, Shandong, CN;

Linlin Hu, Shandong, CN;

Yuhan Zhang, Shandong, CN;

Assignee:

WEIFANG MEDICAL UNIVERSITY, Shandong, CN;

Attorney:

TAROLLI, SUNDHEIM, COVELL & TUMMINO L.L.P.

Primary Examiner:

David J Blanchard

Assistant Examiner:

Alissa Prosser

Int. Cl.
CPC ...
A61L 27/26 (2006.01); A61F 2/30 (2006.01); A61L 27/20 (2006.01); A61L 27/24 (2006.01); A61L 27/48 (2006.01); A61L 27/58 (2006.01); D01D 5/00 (2006.01); D04H 1/4282 (2012.01); D04H 1/435 (2012.01); D04H 1/728 (2012.01); D04H 3/007 (2012.01); D04H 3/011 (2012.01); D04H 3/16 (2006.01); D06M 15/03 (2006.01); D06M 23/10 (2006.01); D06M 101/18 (2006.01); D06M 101/32 (2006.01);
U.S. Cl.
CPC ...
A61L 27/26 (2013.01); A61F 2/30965 (2013.01); A61L 27/20 (2013.01); A61L 27/24 (2013.01); A61L 27/48 (2013.01); A61L 27/58 (2013.01); D01D 5/0038 (2013.01); D01D 5/0084 (2013.01); D04H 1/4282 (2013.01); D04H 1/435 (2013.01); D04H 1/728 (2013.01); D04H 3/007 (2013.01); D04H 3/011 (2013.01); D04H 3/16 (2013.01); D06M 15/03 (2013.01); D06M 23/10 (2013.01); A61L 2400/12 (2013.01); A61L 2430/02 (2013.01); D06M 2101/18 (2013.01); D06M 2101/32 (2013.01); D10B 2321/12 (2013.01); D10B 2331/041 (2013.01); D10B 2509/00 (2013.01);
Abstract

The invention relates to bone repair and more specifically to a berberine/mineralized collagen-based composite membrane, a preparation method, and an application thereof. The composite membrane includes a berberine nanofiber membrane and a mineralized collagen membrane disposed on a unilateral surface of the berberine nanofiber membrane. The mineralized collagen with biomimetic mineralization capacity is combined with a Chinese materia medica monomer, berberine, the resulting bilayer composite membrane has a better effect on promoting osteogenesis In addition, a novel dosage form of berberine is constructed. An electrospinning method prepares a berberine nanofiber membrane. The berberine nanofibers are received by the mineralized collagen membrane, or after the berberine nanofiber membrane is obtained, a mineralized collagen membrane is prepared by applying on the surface of the berberine nanofiber membrane.

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