The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jun. 11, 2024

Filed:

Nov. 09, 2022
Applicants:

California Institute of Technology, Pasadena, CA (US);

University of Southern California, Los Angeles, CA (US);

Inventors:

Yu-Chong Tai, Pasadena, CA (US);

Aubrey M. Shapero, Pasadena, CA (US);

Nicholas E. Scianmarello, Pasadena, CA (US);

Mark S. Humayun, Glendale, CA (US);

Assignees:

California Institute of Technology, Pasadena, CA (US);

University of Southern California, Los Angeles, CA (US);

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61F 9/00 (2006.01); A61K 9/00 (2006.01); A61M 31/00 (2006.01); G02C 7/04 (2006.01);
U.S. Cl.
CPC ...
A61F 9/0017 (2013.01); A61K 9/0051 (2013.01); A61M 31/002 (2013.01); A61F 2250/0068 (2013.01); B01L 2400/082 (2013.01); G02C 7/049 (2013.01);
Abstract

A microfluidic flow restrictor that uses micron-sized beads to impede flow is described. The flow rate can be adjusted by adding or removing the beads using injection needles through self-sealing ports, one injection needle injecting or aspirating beads and another injection needle pushing or pulling fluid from outside of a bead trap within the flow restrictor. In alternative embodiments, the beads or other filler material can be trapped in a manifold bead trap such that they block a subset of fluid channels of the flow restrictor, allowing fluid to flow freely through the rest of the fluid channels. The flow restrictor can be integrated with a contact lens or implantable medical device for use in dispensing liquid therapeutic agents at flow rates of microliters per minute or moving body fluids at a controlled rate from one part of the body to another.


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