The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jun. 04, 2024

Filed:

Jan. 09, 2020
Applicant:

The Regents of the University of Michigan, Ann Arbor, MI (US);

Inventors:

Xudong Fan, Saline, MI (US);

Xueding Wang, Ann Arbor, MI (US);

Xuzhou Li, Ann Arbor, MI (US);

Yu Qin, Ann Arbor, MI (US);

Xiaotian Tan, Ann Arbor, MI (US);

Yu-Cheng Chen, Ann Arbor, MI (US);

Qiushu Chen, Ann Arbor, MI (US);

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
G01N 21/63 (2006.01); A61B 5/00 (2006.01); H01S 3/08 (2023.01); H01S 3/083 (2006.01); H01S 3/094 (2006.01);
U.S. Cl.
CPC ...
G01N 21/63 (2013.01); A61B 5/6876 (2013.01); H01S 3/08059 (2013.01); H01S 3/083 (2013.01); H01S 3/094076 (2013.01); G01N 2201/06113 (2013.01);
Abstract

A laser whose emission is modulated by ultrasound is presented. The laser is usually micron-sized. In response to ultrasound modulation, the laser emission increases and decreases. Such a change in emission can be detected by external optical detectors. This type of laser can be used as a new type of imaging modality, in which laser emission in combination with sound waves or ultrasound waves, is used for imaging Laser emission has a much narrower spectral linewidth and stronger intensity than fluorescence and therefore is able to achieve higher sensitivity, whereas sound waves are used to provide a better spatial resolution of the laser emission from the laser. In ultrasound modulated laser based imaging, multiple lasers can be placed inside cells or tissues.


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