The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 04, 2024
Filed:
Jun. 19, 2020
Hoffmann-la Roche Inc., Little Falls, NJ (US);
Christian Klein, Schlieren, CH;
Ekkehard Moessner, Schlieren, CH;
Lydia Jasmin Hanisch, Schlieren, CH;
Wei Xu, Schlieren, CH;
Camille Loise Sophie Delon, Schlieren, CH;
Diana Darowski, Schlieren, CH;
Christian Jost, Schlieren, CH;
Vesna Pulko, Schlieren, CH;
HOFFMANN-LA ROCHE INC., Little Falls, NJ (US);
Abstract
The present invention generally relates to specificity assays using cell cultures, in particular to chimeric antigen receptor (CAR) expressing reporter T (CAR-T) cell assays to test novel antigen binding moieties in different formats. Furthermore, the present invention relates to the use of CAR-T cells, transfected/transduced with an engineered chimeric antigen receptor (CAR) comprising a target antigen binding moiety capable of specific binding to a recognition domain of an antigen binding molecule. The invention also relates to methods and kits for specificity testing of a candidate antigen binding moiety and/or nucleic acid molecules and vectors expressing engineered CARs.