The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 04, 2024
Filed:
Apr. 10, 2020
Applicant:
Prevail Therapeutics, Inc., New York, NY (US);
Inventors:
Asa Abeliovich, New York, NY (US);
Laura Heckman, New York, NY (US);
Herve Rhinn, New York, NY (US);
Li Chin Wong, New York, NY (US);
Hsuan-Ni Lin, New York, NY (US);
Franz Hefti, New York, NY (US);
Assignee:
Prevail Therapeutics, Inc., New York, NY (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C12N 7/00 (2006.01); A61K 48/00 (2006.01); A61P 25/28 (2006.01); C07K 14/435 (2006.01); C12N 9/02 (2006.01); G01N 33/68 (2006.01);
U.S. Cl.
CPC ...
C12N 7/00 (2013.01); A61K 48/0075 (2013.01); A61K 48/0083 (2013.01); A61P 25/28 (2018.01); C07K 14/435 (2013.01); C12N 9/0071 (2013.01); C12Y 114/18001 (2013.01); G01N 33/6803 (2013.01); C12N 2750/14132 (2013.01); C12N 2750/14133 (2013.01); C12N 2750/14143 (2013.01); G01N 2333/435 (2013.01);
Abstract
The disclosure relates to compositions and methods for treatment of diseases associated with aberrant lysosomal function, such as fronto-temporal dementia (FTD). The disclosure also provides expression constructs comprising a transgene encoding progranulin or a portion thereof. The disclosure provides methods of treating FTD by administering such expression constructs to a subject in need thereof.